Can pyrazinamide cause gout?

Pyrazinamide, an anti-mycobacterial drug, not only induces hyperuricaemia, but may also lead to acute gouty attacks. It is a strong urate retention agent, causing a >80% reduction in renal clearance of uric acid at a 300 mg therapeutic daily dose [24].

Can pyrazinamide increase uric acid?

Antituberculosis medications such as pyrazinamide and ethambutol have been associated with increasing uric acid levels. Although often considered asymptomatic, severe hyperuricemia can ultimately lead to renal failure.

Why is pyrazinamide contraindicated in gout?

The use of pyrazinamide is contraindicated in patients with acute gout. Pyrazinamide inhibits the renal excretion of uric acid, which may frequently result in precipitation or exacerbation of gout. Therapy with pyrazinamide should be administered cautiously in patients with hyperuricemia or a history of gout.

Does pyrazinamide cause joint pain?

SIDE EFFECTS: Nausea, vomiting, loss of appetite, or mild muscle/joint pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Which TB drugs cause gout?

Certain tuberculosis medications, including pyrazinamide and ethambutol, are known to induce hyperuricemia and trigger gout attacks.

Can pyrazinamide increase uric acid?

Antituberculosis medications such as pyrazinamide and ethambutol have been associated with increasing uric acid levels. Although often considered asymptomatic, severe hyperuricemia can ultimately lead to renal failure.

Why is pyrazinamide contraindicated in gout?

The use of pyrazinamide is contraindicated in patients with acute gout. Pyrazinamide inhibits the renal excretion of uric acid, which may frequently result in precipitation or exacerbation of gout. Therapy with pyrazinamide should be administered cautiously in patients with hyperuricemia or a history of gout.

Does pyrazinamide cause joint pain?

SIDE EFFECTS: Nausea, vomiting, loss of appetite, or mild muscle/joint pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Which TB drugs cause gout?

Certain tuberculosis medications, including pyrazinamide and ethambutol, are known to induce hyperuricemia and trigger gout attacks.

How does pyrazinamide cause gout?

Anti-tubercular drugs Pyrazinamide, an anti-mycobacterial drug, not only induces hyperuricaemia, but may also lead to acute gouty attacks. It is a strong urate retention agent, causing a >80% reduction in renal clearance of uric acid at a 300 mg therapeutic daily dose [24].

Why is pyrazinamide contraindicated in gout?

The use of pyrazinamide is contraindicated in patients with acute gout. Pyrazinamide inhibits the renal excretion of uric acid, which may frequently result in precipitation or exacerbation of gout. Therapy with pyrazinamide should be administered cautiously in patients with hyperuricemia or a history of gout.

Can TB medicine increase uric acid?

While receiving anti-TB treatment, an increase in uric acid levels of more than 8 mg/dl was accepted as “hyperuricemia” that is a well-known side effect of PZA. Patients with hyperuricemia and/or arthralgia related to therapy were analyzed for renal disease, concomitant use of loop-inhibiting diuretics.

What drugs increase uric acid levels?

  • chlorothiazide.
  • chlorthalidone.
  • hydrochlorothiazide.
  • indapamide.
  • metolazone.
  • spironolactone.
  • Is pyrazinamide indicated in gout?

    Furthermore, gouty attacks have been associated with patients taking pyrazinamide. Ethambutol can also cause hyperuricemia by decreasing renal uric acid clearance, but it does so less consistently and to a lesser degree than pyrazinamide. Calcineurin inhibitors have also been shown to raise uric acid levels.

    Which medication is contraindicated in gout?

    In addition to diet, exercise, and weight loss, avoid these medications that can trigger gout, if you can: Diuretics (used to treat high blood pressure or heart disease) Salicylate-containing drugs (such as aspirin) Niacin (vitamin B3 and nicotinic acid)

    What are the contraindications of pyrazinamide?

  • diabetes.
  • a type of joint disorder due to excess uric acid in the blood called gout.
  • porphyria.
  • alcoholism.
  • severe liver disease.
  • Which TB drugs cause gout?

    Certain tuberculosis medications, including pyrazinamide and ethambutol, are known to induce hyperuricemia and trigger gout attacks.

    Can TB drugs cause joint pain?

    Common side effects include loss of appetite, nausea and flushing. Some people experience pain in their joints. This is usually mild and painkillers such as aspirin or paracetamol will ease the pain.

    What are the main side effects of pyrazinamide?

  • fever;
  • joint pain or swelling;
  • easy bruising or bleeding (nosebleeds, bleeding gums);
  • gout flare-up symptoms --joint pain, stiffness, redness, or swelling (especially at night); or.
  • Does pyrazinamide increase uric acid?

    Antituberculosis medications such as pyrazinamide and ethambutol have been associated with increasing uric acid levels. Although often considered asymptomatic, severe hyperuricemia can ultimately lead to renal failure.

    When should I stop taking pyrazinamide?

    Your child should start to feel better and have fewer symptoms after taking the TB medicines for about 2 weeks. However, they must continue to take the medicine every day until the doctor says to stop treatment. This will be for 2 months for pyrazinamide and at least 6 months for the other medicines.

    Can TB medicine increase uric acid?

    While receiving anti-TB treatment, an increase in uric acid levels of more than 8 mg/dl was accepted as “hyperuricemia” that is a well-known side effect of PZA. Patients with hyperuricemia and/or arthralgia related to therapy were analyzed for renal disease, concomitant use of loop-inhibiting diuretics.

    Can isoniazid cause gout?

    PZA (applies to isoniazid/pyrazinamide/rifampin) gout Pyrazinamide inhibits the renal excretion of uric acid, which may frequently result in precipitation or exacerbation of gout. Therapy with pyrazinamide should be administered cautiously in patients with hyperuricemia or a history of gout.

    What medications cause uric acid?

  • chlorothiazide.
  • chlorthalidone.
  • hydrochlorothiazide.
  • indapamide.
  • metolazone.
  • spironolactone.
  • Can TB drugs cause joint pain?

    Common side effects include loss of appetite, nausea and flushing. Some people experience pain in their joints. This is usually mild and painkillers such as aspirin or paracetamol will ease the pain.

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